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ChemicalBook--->CAS DataBase List--->1119276-80-0

1119276-80-0

1119276-80-0 Structure

1119276-80-0 Structure
IdentificationBack Directory
[Name]

Sodium Lifitegrast
[CAS]

1119276-80-0
[Synonyms]

Xiidra
SAR 1118-023
Lifitegrast sodium
Sodium Lifitegrast
LIFITEGRAST SODIUM; SAR-1118-023; SAR 1118-023; SAR1118-023; XIIDRA
N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-, sodium salt (1:1)
[Molecular Formula]

C29H25Cl2N2NaO7S
[MDL Number]

MFCD33029276
[MOL File]

1119276-80-0.mol
[Molecular Weight]

639.48
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease[1].
[in vivo]

Lifitegrast has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior[2].

[IC 50]

αLβ2
[References]

[1] Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15. DOI:10.1016/j.jtos.2016.01.001
[2] Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402. DOI:10.1089/jop.2012.0102
[3] Rao VR, et al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin(STZ) model of diabetic retinopathy (DR). Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5198-204. DOI:10.1167/iovs.09-5144
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