天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->1118460-77-7

1118460-77-7

1118460-77-7 Structure

1118460-77-7 Structure
IdentificationBack Directory
[Name]

UCPH-101
[CAS]

1118460-77-7
[Synonyms]

CS-2757
UCPH-101
UCPH-101; UCPH 101; UCPH101
2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
[Molecular Formula]

C27H22N2O3
[MOL File]

1118460-77-7.mol
[Molecular Weight]

422.48
Chemical PropertiesBack Directory
[Melting point ]

194.0-197.2 °C
[Boiling point ]

703.5±60.0 °C(Predicted)
[density ]

1.32±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

Soluble in DMSO (up to 10 mg/ml).
[form ]

solid
[pka]

3.23±0.60(Predicted)
[color ]

Off-white
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P280-P305+P351+P338
Hazard InformationBack Directory
[Description]

UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system. UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 μM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier.
[Uses]

UCPH 101 is a subtype-selective inhibitor of human excitatory amino acid transporter subtype 1.
[storage]

Store at +4°C
[References]

1) Jensen?et al.?(2009),?Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1; J. Med. Chem.,?52?912 2) Erichsen?et al.?(2010),?Structure-Activity Relationship Study of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101); J. Med. Chem.,?53?7180 3) Corbetta?et al.?(2019),?Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma; Int. J. Cancer,?144?2539
1118460-77-7 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289 , +8618813727289
Website: http://www.trustwe.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207 , +8617767106207
Website: https://www.molcore.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Website: http://m.approvedhomemanagement.com/ShowSupplierProductsList13285/0.htm
Company Name: Ascent Scientific  
Tel: 4401179829988
Website: www.ascentscientific.com
Company Name: Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.  
Tel: 025-66099280 17798518460
Website: http://www.aikonchem.com/
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Website: http://www.isunpharm.com
Company Name: AdooQ Bioscience CHINA  
Tel: 025-58849295 18951903616;
Website: http://www.adooq.cn
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696,15000506266 15000506266
Website: http://www.bioll.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Website: http://www.cw-bio.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 17754423994 17754423994
Website: https://www.biochempartner.com
Tags:1118460-77-7 Related Product Information
5812-07-7 75747-14-7 208260-29-1 2271358-65-5

This site uses cookies
This website uses cookies and similar technologies to store and retrieve information about your use of this website. This information helps us to provide, analyse and improve our services, which may include personalised content or advertising. We may share this information with Google and other third parties. This cookies are necessary for our website to work properly . By clicking "Continue" or continuing to browse our site you are agreeing to our and our partners use of cookies.
Accept