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ChemicalBook--->CAS DataBase List--->111112-18-6

111112-18-6

111112-18-6 Structure

111112-18-6 Structure
IdentificationBack Directory
[Name]

Benzamide,4-[3-[[(2R)-2-hydroxy-2-phenylethyl]amino]-3-methylbutyl]-, monohydrochloride(9CI)
[CAS]

111112-18-6
[Synonyms]

LY195448 HCl
UNII-BR0DFE3GF6
Benzamide,4-[3-[[(2R)-2-hydroxy-2-phenylethyl]amino]-3-methylbutyl]-, monohydrochloride(9CI)
[Molecular Formula]

C20H27ClN2O2
[MOL File]

111112-18-6.mol
[Molecular Weight]

362.9
Hazard InformationBack Directory
[Uses]

LY-195448 hydrochloride is a phenethanolamine that exhibits anti-tumour activity across various murine tumour models. LY-195448 hydrochloride acts by blocking cells at metaphase. LY-195448 hydrochloride has demonstrated a lack of "standard" side effects commonly associated with cancer treatments, such as myelosuppression and gastrointestinal toxicity. LY-195448 hydrochloride was evaluated in a phase I trial, where it showed only mild and reversible side effects like hypotension, tachycardia, and tremor.
[References]

[1] Phase I clinical and pharmacokinetic study of LY 195448
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