Chemical Properties | Back Directory | [Boiling point ]
588.8±60.0 °C(Predicted) | [density ]
2.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mM | [form ]
A crystalline solid | [pka]
3.43±0.10(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 μM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 μM, 15.25 μM, and 11.9 μM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1]. | [IC 50]
CK2: 0.5 μM (IC50); CK2: 0.25 μM (Ki); ERK8: 0.5 μM (IC50); PIM1: 8.65 μM (Ki); HIPK2: 15.25 μM (Ki); DYRK1A: 11.9 μM (Ki); Apoptosis | [storage]
Store at -20°C | [References]
[1] Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65. DOI:10.1042/BJ20080309 |
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