| Identification | Back Directory | [Name]
ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE | [CAS]
107905-52-2 | [Synonyms]
Ethyl 2-(2,2,2-Trifluoroethyl Phosphono)propionate
ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE
2-[Bis(2,2,2-trifluoroethoxy)phosphinyl]propanoic Acid Ethyl Ester | [Molecular Formula]
C9H13F6O5P | [MDL Number]
MFCD04039536 | [MOL File]
107905-52-2.mol | [Molecular Weight]
346.16 |
| Chemical Properties | Back Directory | [Appearance]
Colourless Liquid | [Boiling point ]
115-120°C/20mmHg | [density ]
1.381±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Clear Colourless to Pale Yellow | [CAS DataBase Reference]
107905-52-2 |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Liquid | [Uses]
A wittig reagent | [Synthesis]
KHMDS (7.50 mL, 3.75 mmol, 0.5 M in toluene) was added to a solution of 18-
crown-6 (4.10 g, 15.51 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1)
(0.50 mL, 3.41 mmol) by syringe in a dropwise manner at -78 ℃. Following 15 min,
ethyl 2-bromopropionate (0.40 mL, 3.08 mmol) was added to the round bottom flask and
the reaction mixture was allowed to stir for 4 hr at room temperature. Following the
standard workup procedure, the crude product was then purified by flash column
chromatography (3:1 to 2:1 hexanes:EtOAc, Rf
= 0.33 in 1:1 hexanes:EtOAc) yielding
Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate (112 mg, 0.33 mmol, 10.5%) as a yellow syrup. |
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