| Identification | Back Directory | [Name]
N-succinimidyl-3-(2-pyridyldithio)butyrate | [CAS]
107348-47-0 | [Synonyms]
PPC-NHS ester
N-succinimidyl-3-(2-pyridyldithio)butyrate
2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate
Butanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C13H14N2O4S2 | [MDL Number]
MFCD28398150 | [MOL File]
107348-47-0.mol | [Molecular Weight]
326.39 |
| Hazard Information | Back Directory | [Uses]
PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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