| Chemical Properties | Back Directory | [Boiling point ]
517.3±50.0 °C(Predicted) | [density ]
1.212±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.42±0.20(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Description]
ML359 is an inhibitor of protein disulfide isomerase. | [Uses]
ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo[1][2]. | [in vivo]
ML359 inhibits of thrombus formation in a mouse laser injury model[2]. | [References]
[1] Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12. PMID:24624466
[2] Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21): 2880. |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
|