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ChemicalBook--->CAS DataBase List--->1059070-10-8

1059070-10-8

1059070-10-8 Structure

1059070-10-8 Structure
IdentificationBack Directory
[Name]

DSR 6434
[CAS]

1059070-10-8
[Synonyms]

DSR 6434
6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
[Molecular Formula]

C19H28N8O2
[MOL File]

1059070-10-8.mol
[Molecular Weight]

400.48
Chemical PropertiesBack Directory
[density ]

1.283±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM)
[form ]

A solid
[pka]

10.22±0.20(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility.
[Biological Activity]

DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect.
[in vitro]

To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation.
[target]

TLR7

7.2 nM (EC 50 , Human)

TLR7

4.6 nM (EC 50 , Mice)

[storage]

Store at -20°C
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