| Identification | Back Directory | [Name]
DSR 6434 | [CAS]
1059070-10-8 | [Synonyms]
DSR 6434
6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro- | [Molecular Formula]
C19H28N8O2 | [MOL File]
1059070-10-8.mol | [Molecular Weight]
400.48 |
| Chemical Properties | Back Directory | [density ]
1.283±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM) | [form ]
A solid | [pka]
10.22±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility. | [Biological Activity]
DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect. | [in vitro]
To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. | [target]
| TLR7 7.2 nM (EC 50 , Human) | TLR7 4.6 nM (EC 50 , Mice) | | [storage]
Store at -20°C |
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| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
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