| Identification | Back Directory | [Name]
[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate | [CAS]
10527-47-6 | [Synonyms]
GpppA
Guanosine triphosphate adenosine
guanosine 5'-triphosphate-5'-adenosine
[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate | [Molecular Formula]
C20H27N10O17P3 | [MDL Number]
MFCD34474135 | [MOL File]
10527-47-6.mol | [Molecular Weight]
772.41 |
| Hazard Information | Back Directory | [Uses]
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog[1][2]. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26(49):11266-11275. DOI:10.1002/chem.202001036
[2] Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12(12):4383-4388. DOI:10.1039/d1sc00159k |
|
|