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ChemicalBook--->CAS DataBase List--->1052515-37-3

1052515-37-3

1052515-37-3 Structure

1052515-37-3 Structure
IdentificationBack Directory
[Name]

NSC 145366
[CAS]

1052515-37-3
[Synonyms]

NSC 145366
[Molecular Formula]

C37H63ClN2O4
[MOL File]

1052515-37-3.mol
[Molecular Weight]

635.37
Hazard InformationBack Directory
[Description]

NSC145366 is an inhibitor of Hsp90 activities which targets the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. NSC145366 increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119μM) but does not compete with NTD or CTD-ATP binding.
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