| Identification | Back Directory | [Name]
3alpha-Akeboic acid | [CAS]
104777-61-9 | [Synonyms]
3alpha-Akeboic acid
3-Epiakebonoic acid
3alpha-Akebonoic acid
(3alpha)-3-Hydroxy-30-noroleana-12,20(29)-dien-28-oic acid
30-Noroleana-12,20(29)-dien-28-oic acid, 3-hydroxy-, (3α)- | [Molecular Formula]
C29H44O3 | [MDL Number]
MFCD20260963 | [MOL File]
104777-61-9.mol | [Molecular Weight]
440.658 |
| Hazard Information | Back Directory | [Description]
3α-Akebonoic acid shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, it also shows significant in vitro α-glucosidase inhibitory activity.
3α-Akebonoic acid can interfer with presenilin-1 (PS1)/ β-site APP-cleaving enzyme 1 (BACE1) interaction and reduces Aβ production, the chemical interference of PS1/BACE1 interaction is a promising strategy for Alzheimer’s disease therapeutics. | [Uses]
3α-Akebonoic acid is a α-glucosidase inhibitor with an IC50 value of 0.035 mM. 3α-Akebonoic acid shows antibacterial activity and cytotoxicity[1]. | [target]
Beta Amyloid | BACE | [References]
[1] Wang J, et al. Bioactive 30-noroleanane triterpenes from the pericarps of Akebia trifoliata. Molecules. 2014 Apr 4;19(4):4301-12. DOI:10.3390/molecules19044301 |
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