| Identification | Back Directory | [Name]
METHOXYCARBONYL-D-NLE-GLY-ARG-PNA | [CAS]
104186-68-7 | [Synonyms]
MOC-D-Nle-GR-pNA
MOC-D-NLE-GLY-ARG-PNA
METHOXYCARBONYL-D-NLE-GLY-ARG-PNA
L-Argininamide, N-(methoxycarbonyl)-D-norleucylglycyl-N-(4-nitrophenyl)- (9CI) | [Molecular Formula]
C22H34N8O7 | [MDL Number]
MFCD08702752 | [MOL File]
104186-68-7.mol | [Molecular Weight]
522.55 |
| Hazard Information | Back Directory | [Uses]
Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin that can serve as a substrate for coagulation factors IXa (FIXa) and Xa (FXa)[1][2][3]. | [References]
[1] Hopfner KP, et al. New enzyme lineages by subdomain shuffling. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9813-8. DOI:10.1073/pnas.95.17.9813
[2] Hopfner KP, et al. Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants. EMBO J. 1997 Nov 17;16(22):6626-35. DOI:10.1093/emboj/16.22.6626
[3] Sturzebecher J, et al. Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols. FEBS Lett. 1997 Jul 28;412(2):295-300. DOI:10.1016/s0014-5793(97)00811-9 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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