| Identification | Back Directory | [Name]
5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinicacid | [CAS]
1039758-22-9 | [Synonyms]
MK-4074
MK 4074,MK4074
5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinicacid
sodium5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinate
3-Pyridinecarboxylic acid, 5-[1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]-3,4-dihydro-4-oxospiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]- | [Molecular Formula]
C33H31N3O6 | [MDL Number]
MFCD31630723 | [MOL File]
1039758-22-9.mol | [Molecular Weight]
565.62 |
| Chemical Properties | Back Directory | [Boiling point ]
875.4±65.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.3 mg/mL (147.27 mM) | [form ]
Solid | [pka]
2.11±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MK-4074, strongly inhibits acetyl-CoA carboxylase, both ACC1 and ACC2 with IC50 values of approximately 3 nM. s highly liver specific because it is a substrate of organic anion transport protein (OATP) transporters that are present only in hepatocytes. | [in vivo]
In male KKAy mice, a mouse model of obesity, type 2 diabetes, and fatty liver, a single oral dose of MK-4074 (0.3-3 mg/kg) significantly decreases DNL in a dose-dependent manner with an ID50 value of 0.9 mg/kg 1 hr post-administration. In a time course study, MK-4074 orally at 30 mg/kg reduces hepatic DNL by 83%, 70%, and 51% at 4, 8, and 12 hr post-dose, respectively. Single oral doses of MK-4074 at 30 and 100 mg/kg significantly increases plasma total ketones, a surrogate biomarker for hepatic FAO, by 1.5-fold to 3-fold for up to 8 hr[1]. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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