| Identification | Back Directory | [Name]
PF-03654746, 4-Methylbenzenesulfonate (1:1) | [CAS]
1039399-17-1 | [Synonyms]
PF3654746
PF-03654746 Tosylate
IKAYTZLLIWAEDV-WXWMPIANSA-N
PF03654746 Tosylate,PF 03654746 Tosylate
PF-03654746, 4-Methylbenzenesulfonate (1:1)
trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(1-pyrrolidinylmethyl)phenyl]-cyclobutanecarboxamide 4-methylbenzenesulfonate | [Molecular Formula]
C25H32F2N2O4S | [MDL Number]
MFCD14635201 | [MOL File]
1039399-17-1.mol | [Molecular Weight]
494.6 |
| Hazard Information | Back Directory | [Uses]
PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2]. | [References]
[1] Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. DOI:10.1016/j.jaci.2011.11.026
[2] Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46. DOI:10.1124/jpet.110.166876
[3] Wager TT, et, al. Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-meth DOI:10.1021/jm200939b |
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