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ChemicalBook--->CAS DataBase List--->1032349-93-1

1032349-93-1

1032349-93-1 Structure

1032349-93-1 Structure
IdentificationBack Directory
[Name]

MK-2206
[CAS]

1032349-93-1
[Synonyms]

MK-2206(FREE BASE)
8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-ol
1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-
[Molecular Formula]

C25H21N5O
[MDL Number]

MFCD12912151
[MOL File]

1032349-93-1.mol
[Molecular Weight]

407.47
Hazard InformationBack Directory
[Uses]

A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.
[Definition]

ChEBI: MK-2206 is an organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted at positions 8 and 9 respectively by 4-(1-aminocyclobutyl)phenyl and phenyl groups. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is functionally related to a 1,6-naphthyridine.
[IC 50]

Akt1: 8 nM (IC50); Akt2: 12 nM (IC50); Akt3: 65 nM (IC50)
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