| Identification | Back Directory | [Name]
MK-2206 | [CAS]
1032349-93-1 | [Synonyms]
MK-2206(FREE BASE)
8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-ol
1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl- | [Molecular Formula]
C25H21N5O | [MDL Number]
MFCD12912151 | [MOL File]
1032349-93-1.mol | [Molecular Weight]
407.47 |
| Hazard Information | Back Directory | [Uses]
A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM. | [Definition]
ChEBI: MK-2206 is an organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted at positions 8 and 9 respectively by 4-(1-aminocyclobutyl)phenyl and phenyl groups. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is functionally related to a 1,6-naphthyridine. | [IC 50]
Akt1: 8 nM (IC50); Akt2: 12 nM (IC50); Akt3: 65 nM (IC50) |
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| Company Name: |
NCE Biomedical Co.,Ltd.
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Hui Chem Co., Ltd.
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Tcichem, Inc.
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