| Identification | Back Directory | [Name]
Fosdevirine | [CAS]
1018450-26-4 | [Synonyms]
Fosdevirine
GSK 2248761
GSK 2248761A
Phosphinic acid, P-[2-(aminocarbonyl)-5-chloro-1H-indol-3-yl]-P-[3-[(1E)-2-cyanoethenyl]-5-methylphenyl]-, methyl ester, [P(R)]- | [Molecular Formula]
C20H17ClN3O3P | [MOL File]
1018450-26-4.mol | [Molecular Weight]
413.8 |
| Hazard Information | Back Directory | [Uses]
Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572)-resistant clinical isolates[1]. | [IC 50]
HIV-1; HIV-1 (K103N); HIV-1 (Y181C) | [References]
[1] Castellino S, et al. Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity. Chem Res Toxicol. 2013 Feb 18;26(2):241-51. DOI:10.1021/tx3004196 |
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