| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- | [CAS]
1010100-28-3 | [Synonyms]
Lenalidomide-5-aminomethyl
3-[5-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione
3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- | [Molecular Formula]
C14H15N3O3 | [MDL Number]
MFCD31692700 | [MOL File]
1010100-28-3.mol | [Molecular Weight]
273.29 |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1]. | [IC 50]
Cereblon | [References]
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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