| Identification | Back Directory | [Name]
H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 | [CAS]
100853-58-5 | [Synonyms]
WIPTIDE
PKI (5-22), AMIDE
TTYADFIASGRTGRRNAI-NH2
PKA INHIBITOR (5-22) AMIDE
PROTEIN KINASE A INHIBITOR (5-22) AMIDE
CAMP DEPENDENT PK INHIBITOR (5-22) AMIDE
PKI-ALPHA (5-22) AMIDE (HUMAN, MOUSE, RABBIT, RAT)
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-22) AMIDE
PKI-a (5-22) aMide (huMan, Mouse, rabbit, rat), Wiptide
cAMP-Dependent Protein Kinase Inhibitor (5-22), amide, Wiptide
THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
cAMP-Dependent Protein Kinase Inhibitor-a (5-22) aMide (huMan, Mouse, rabbit, rat)
cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR-ALPHA (5-22) AMIDE (HUMAN, MOUSE, RABBIT, RAT)
THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP: TTYADFIASGRTGRRNAIHD
L-Isoleucinamide, L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl- (9CI) | [Molecular Formula]
C84H137N29O26 | [MDL Number]
MFCD00214600 | [MOL File]
100853-58-5.mol | [Molecular Weight]
1969.17 |
| Hazard Information | Back Directory | [Uses]
PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2]. | [References]
[1] Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. DOI:10.1152/ajpregu.2001.280.4.R935
[2] Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80. DOI:10.1042/bj2640371 |
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