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Pharmaceutical intermediates

Pharmaceutical intermediates are the drugs used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry.

Q:How to prepare N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine?

A:N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine can be prepared from 2-ethylaniline by nitration, cyclization and methylation reactions.

Jul 28,2025  Pharmaceutical intermediates

Application research of (D)-2-alaninol

(D)-2-Alaninol is one of the raw materials for synthesizing the ofloxacin. This article will introduce other application research of this product.

Jul 24,2025  Pharmaceutical intermediates

Synthesis, Solubility, and Bioproduction of 5-Methyl-2-pyrazinecarboxylic Acid

5-Methyl-2-pyrazinecarboxylic acid is a critical pharmaceutical intermediate for synthesizing drugs like glipizide, acimox, and tuberculosis medications.

Jun 11,2025  Pharmaceutical intermediates

3-Butylidenephthalide: Repellency, Toxicity, and Antifibrotic Potential

3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache.

May 29,2025  Pharmaceutical intermediates

Two methods for determination of 1-methylpyrrolidine

1-Methylpyrrolidine is an organic base and inactive to UV absorption. The following are two research reports on the detection method of 1-methylpyrrolidine.

May 26,2025  Pharmaceutical intermediates

2,4-Dichlorobenzyl alcohol: pharmacological action and applications

2,4-Dichlorobenzyl alcohol is a mild antiseptic with a wide range of effects on bacterial and viral oral and throat infections.

May 20,2025  Pharmaceutical intermediates

Application researchers of 4-cyanopyridine

4-Cyanopyridine has been used in the agricultural and pharmaceutical industries. This article mainly summarizes its other application studies.

May 14,2025  Pharmaceutical intermediates

Mechanism and Toxicity of 2-Oxazolidone

In the field of medicinal chemistry, 2-oxazolidinone has been proven as a preferred scaffold for the development of novel medicines for various diseases.

May 12,2025  Pharmaceutical intermediates

Synthesis of N-phenylanthranilic Acid and Its Related Toxicity and Biomarker Studies

This article covers the synthesis of N-phenylanthranilic acid, its impact on rats as a chloride channel blocker, and related biomarker studies.

May 8,2025  Pharmaceutical intermediates

Sitagliptin phosphate: Mechanism,Pharmacokinetics and Pharmacodynamics

Sitagliptin phosphate, the first dipeptidyl peptidase 4 (DPP-4) inhibitor, provides a new treatment option for patients with type 2 diabetes.

May 8,2025  Pharmaceutical intermediates
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